Coenzyme Q10 and remacemide hydrochloride ameliorate motor deficits in a Huntington's disease transgenic mouse model
G Schilling, ML Coonfield, CA Ross, DR Borchelt - Neuroscience letters, 2001 - Elsevier
G Schilling, ML Coonfield, CA Ross, DR Borchelt
Neuroscience letters, 2001•ElsevierHuntington's disease (HD) is a progressive inherited neurodegenerative disorder, for which
there is no effective therapy. The CARE-HD study, recently published, evaluated the ability
of a combination of coenzyme Q10 (CoQ10) and remacemide hydrochloride (R) to
ameliorate symptoms, which might arise from glutamate-mediated excitotoxicity and
abnormalities in mitochondrial energy production. In this study, we examined the efficacy of
CoQ10/R therapy on ameliorating the motor dysfunction and premature death of HD-N171 …
there is no effective therapy. The CARE-HD study, recently published, evaluated the ability
of a combination of coenzyme Q10 (CoQ10) and remacemide hydrochloride (R) to
ameliorate symptoms, which might arise from glutamate-mediated excitotoxicity and
abnormalities in mitochondrial energy production. In this study, we examined the efficacy of
CoQ10/R therapy on ameliorating the motor dysfunction and premature death of HD-N171 …
Huntington's disease (HD) is a progressive inherited neurodegenerative disorder, for which there is no effective therapy. The CARE-HD study, recently published, evaluated the ability of a combination of coenzyme Q10 (CoQ10) and remacemide hydrochloride (R) to ameliorate symptoms, which might arise from glutamate-mediated excitotoxicity and abnormalities in mitochondrial energy production. In this study, we examined the efficacy of CoQ10/R therapy on ameliorating the motor dysfunction and premature death of HD-N171-82Q transgenic mice. Motor performance, measured on the Rotarod, was specifically but transiently improved beginning 3 weeks after initiating the CoQ10/R therapy. Survival, however was not prolonged. Our findings suggest that further study of CoQ10/R in mouse models is warranted to investigate whether this therapeutic approach can ameliorate the symptoms of HD in early stages of the disease.
Elsevier
