Regulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol
Y Lange, J Ye, M Rigney, TL Steck - Journal of lipid research, 1999 - ASBMB
The abundance of cell cholesterol is governed by multiple regulatory proteins in the
endoplasmic reticulum (ER) which, in turn, are under the control of the cholesterol in that
organelle. But how does ER cholesterol reflect cell (mostly plasma membrane) cholesterol?
We have systematically quantitated this relationship for the first time. We found that ER
cholesterol in resting human fibroblasts comprised∼ 0.5% of the cell total. The ER pool rose
by more than 10-fold in less than 1 h as cell cholesterol was increased by∼ 50% from below …
endoplasmic reticulum (ER) which, in turn, are under the control of the cholesterol in that
organelle. But how does ER cholesterol reflect cell (mostly plasma membrane) cholesterol?
We have systematically quantitated this relationship for the first time. We found that ER
cholesterol in resting human fibroblasts comprised∼ 0.5% of the cell total. The ER pool rose
by more than 10-fold in less than 1 h as cell cholesterol was increased by∼ 50% from below …