Background Four types of malaria vaccine, SPf66 and MSP/RESA vaccines (against the
asexual stages of the Plasmodium parasite) and CS‐NANP and RTS, S vaccines (against
the sporozoite stages), have been tested in randomized controlled trials in endemic areas.
Objectives To assess malaria vaccines against Plasmodium falciparum, P. vivax, P. malariae
and P ovale in preventing infection, disease and death. Search methods We searched the
Cochrane Infectious Diseases Group Specialized Register (April 2004), CENTRAL (The …

Background A malaria vaccine is badly needed. SPf66 was one of the earliest vaccines
developed. It is a synthetic peptide vaccine containing antigens from the blood stages of
malaria linked together with an antigen from the sporozoite stage, and is targeted mainly
against the blood (asexual) stages. Objectives To assess the effect of SPf66 malaria
vaccines against Plasmodium falciparum, P. vivax, P. malariae, and P. ovale in preventing
infection, disease, and death. Search methods We searched the Cochrane Infectious …

Background Vaccines against all stages of the malaria parasite are in development, mainly
for Plasmodium falciparum, which causes the most serious form of malaria. Pre‐erythrocytic
vaccines act to prevent or delay a malaria attack by attacking the sporozoite and liver stages
before the parasite reaches the bloodstream. Objectives To assess the efficacy and safety of
pre‐erythrocytic malaria vaccines against any type of human malaria. Search methods In
March 2006, we searched the Cochrane Infectious Diseases Group Specialized Register …

Background A malaria vaccine is needed because of the heavy burden of mortality and
morbidity due to this disease. This review describes the results of trials of blood (asexual)‐
stage vaccines. Several are under development, but only one (MSP/RESA, also known as
Combination B) has been tested in randomized controlled trials. Objectives To assess the
effect of blood‐stage malaria vaccines in preventing infection, disease, and death. Search
methods In March 2006, we searched the Cochrane Infectious Diseases Group Specialized …